SYSTEMIC USE:
Neonates:
Anaerobic infections: Oral, I.V.:
0-4 weeks: <1200 g:
7.5 mg/kg/dose every 48 hours.
Postnatal age <7 days:
1200-2000 g:
7.5 mg/kg/day every 24 hours;
>2000 g:
15 mg/kg/day in divided doses every 12 hours.
Postnatal age >7 days:
1200-2000 g:
15 mg/kg/day in divided doses every 12 hours;
>2000 g:
30 mg/kg/day in divided doses every 12 hours.
Infants and Children:
Amebiasis:Oral:
35-50 mg/kg/day in divided doses every 8 hours for 10 days.
Trichomoniasis: Oral:
15-30 mg/kg/day in divided doses every 8 hours for 7 days.
Anaerobic infections:
Oral:
15-35 mg/kg/day in divided doses every 8 hours.
I.V.:
30 mg/kg/day in divided doses every 6 hours.
Clostridium difficile (antibiotic-associated colitis):Oral:
20 mg/kg/day divided every 6 hours; Maximum dose: 2 g/day.
Adults:
Amebiasis:Oral:
500-750 mg every 8 hours for 5-10 days.
Trichomoniasis: Oral:
250 mg every 8 hours for 7 days or 2 g as a single dose.
Anaerobic infections: Oral, I.V.:
500 mg every 6-8 hours, not to exceed 4 g/day.
Antibiotic-associated pseudomembranous colitis: Oral:
250-500 mg 3-4 times/day for 10-14 days.
H. pylori:
1 capsule with meals and at bedtime for 14 days in combination with other agents (eg, tetracycline, bismuth subsalicylate, and H2 antagonist).
Vaginosis:
1 applicatorful (~37.5 mg metronidazole) intravaginally once or twice daily for 5 days; apply once in morning and evening if using twice daily, if daily, use at bedtime.
Elderly:
Use lower end of dosing recommendations for adults, do not administer as a single dose.
Dosing adjustment in renal impairment / Hemodialysis / Peritoneal dialysis:
Clcr<10 ml/min:
Administer 50% of normal dose.
* Extensively removed by hemodialysis and peritoneal dialysis (50% to 100%); administer dose posthemodialysis.
Continuous arteriovenous or venovenous hemofiltration:
Administer usual dose.
TOPICAL USE:
Apply and rub a thin filmtwice a day, morning and evening, to entire affected areas after washing. Significant therapeutic results should be noticed within 3 weeks. Clinical studies have demonstrated continuing improvement through 9 weeks of therapy.
Route of administration:
The contents of 1 bottle are to be infused slowly IV, usually in 60 minutes, but can be given in 20 minutes.