Daptomycin Trima is indicated for the treatment of the infections listed below.- Complicated Skin and Skin Structure InfectionsComplicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: Staphylococcus aureus (including methicillin-resistant isolates), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae subsp. equisimilis, and Enterococcus faecalis (vancomycin-susceptible isolates only).- Staphylococcus aureus Bloodstream Infections (Bacteremia), Including those withRight-Sided Infective Endocarditis, Caused by Methicillin-Susceptible and MethicillinResistant Isolates Staphylococcus aureus bloodstream infections (bacteremia), including those with right-sided infective endocarditis, caused by methicillin-susceptible and methicillin-resistant isolates.Combination therapy may be clinically indicated if the documented or presumed pathogens include Gram negative or anaerobic organism